Editorial Commentary Spreading Depression and Cgrp Sumatriptan and Membrane Potential
نویسنده
چکیده
In this issue of the journal the editors have initiated an historical section. Hansreudi Isler presents a scholarly paper on cluster headache. Apparently, this case report is the earliest description of this disorder which satisfies the new diagnostic criteria of the IHS classification, an admirable example of the ancient and modem. There are many points of value in this work, even a therapeutic tip that could still be pursued. This paper, considered in the light of Carlyle’s wisdom, exemplifies why we believe our readers will consider a periodic step back into the history of headache a rewarding venture. In anticipation of this, we have asked Dr Isler to accept the formal editorship of the Historical Section for future issues. He is well known to many of you as a scholar in the Classics as well as Clinical Neurology, who has long provided contemporary headache science with historical perspective and insight. No-one in our specialty is better suited to take this editorship. I encourage our readers to submit papers of historical interest related to headache and associated disorders directly to Dr Isler at the Neurology Clinic, Zurich University Hospital, CH8091, Zurich, Switzerland. Please support him in making this a regular feature of Cephalalgia.
منابع مشابه
Triptans disrupt brain networks and promote stress-induced CSD-like responses in cortical and subcortical areas.
A number of drugs, including triptans, promote migraine chronification in susceptible individuals. In rats, a period of triptan administration over 7 days can produce "latent sensitization" (14 days after discontinuation of drug) demonstrated as enhanced sensitivity to presumed migraine triggers such as environmental stress and lowered threshold for electrically induced cortical spreading depre...
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BACKGROUND The complex pathophysiology of migraine is not yet clearly understood; therefore, experimental models are essential for the investigation of the processes related to migraine headache, which include cortical spreading depression (CSD) and NO donor-induced neurovascular changes. Data on the assessment of drug efficacy in these models are often limited, which prompted us to investigate...
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Calcitonin gene-related peptide (CGRP) is involved in the underlying pathophysiology of all vascular headaches, including migraines. Elevated levels of CGRP during migraine are restored to normal coincident with headache relief after treatment with the antimigraine drug sumatriptan. We have used primary cultures of trigeminal neurons under conditions simulating migraine pathology and therapy to...
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We have investigated the regulation of calcitonin gene-related peptide (CGRP) release from trigeminal neurons by the serotonergic antimigraine drug sumatriptan. Serum levels of the neuropeptide CGRP are elevated during migraine. Treatment with the drug sumatriptan returns CGRP levels to normal coincident with the alleviation of headache. However, despite this clinical efficacy, the cellular tar...
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